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KMID : 0043320170400060704
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Archives of Pharmacal Research
2017 Volume.40 No. 6 p.704 ~ p.712
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Neuroprotective compounds from Reynoutria sachalinensis
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Eom Min-Rye
Weon Jin-Bae
Jung Youn-Sik
Ryu Ga-Hee
Yang Woo-Seung
Ma Choong-Je
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Abstract
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Glutamate is a neurotransmitter in central nervous system. Overexpression of glutamate leads to oxidative stress, resulting in several neurodegenerative disorders that include Alzheimer’s disease. The n-hexane fraction of stems and ethyl acetate (EtOAc) fraction of flowers of Reynoutria sachalinensis provide neuroprotection against glutamate-induced oxidative toxicity in HT22 cells. In this study, 1-decanol (1), β-amyrin (2), dammaran-3β-ol (3), campesterol (4), daucosterol (5), ergosterol peroxide (6), emodin 8-O-β-d-glucopyranoside (7), quercetin (8) and isoquercitrin (9) were isolated from n-hexane fractions of stems and EtOAc fractions of flowers of R. sachalinensis. Their neuroprotective activity was evaluated by MTT assay. 1-Decanol, campesterol, ergosterol peroxide, quercetin and isoquercitrin exhibited neuroprotective activity. These compounds decreased reactive oxygen species level, showed anti-oxidant activity with DPPH radical and in a H2O2 scavenging assay. Therefore, the neuroprotective activity of 1-decanol, campesterol, ergosterol peroxide, quercetin and isoquercitrin are associated with antioxidant activity.
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KEYWORD
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R. sachalinensis, Glutamate, Neuroprotective activity, Anti-oxidant activity
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